Dr. Mark Mattson Dr. Mark Mattson is a professor of neuroscience at the Johns Hopkins University School of Medicine and the former chief of the Neuroscience Research Laboratory at the National Institute on Aging. He's one of the most cited neuroscientists in the world, with more than 180,000 citations noted in the scientific literature. Dr. Mattson's work has advanced scientific understanding of brain aging and identified fundamental aspects of neurodegenerative disorders, including Alzheimer’s disease and Parkinson’s disease. His most notable work has focused on how the brain responds to mild stressors, such as those associated with exercise and intermittent fasting. In this episode, we discuss... 00:3:31 - Hormetic stressors drive adaptation and prevent physiological complacency 00:13:00 - Intermittent fasting improves health by promoting metabolic switching 00:16:49 - Daily time-restricted eating vs 5:2 weekly fasting  00:27:44 - A ketogenic diet and intermittent fasting differ in terms of brain effects 00:34:23 - Exercising while intermittent fasting exerts additive effects 00:52:32 - Plant-based bioactive compounds induce hormetic stress 01:10:48 - Severe caloric restriction may compromise muscle mass 01:26:25 - Intermittent fasting in young vs. old and in men vs. in women 01:35:20 - The effects of cortisol differ during a fast versus chronic stress 01:53:36 - Fasting-mimetics like resveratrol and spermidine vs actual fasting 02:08:44 - How ketone supplementation may improve brain health Join over 300,000 people and get the latest distilled information on circadian insights straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor