Pre-exposure prophylaxis, also known as PrEP, is a highly effective way to prevent HIV infection. While we are most familiar with the pill that is taken every day, there are new long acting injectables coming down the pipeline, with the potential to improve PrEP adherence. Roughly 1 in 5 people who use drugs are at very high risk of getting HIV. Despite this, very few of them are actually getting PrEP. To hear more about these new advancements in PrEP, and how we can close the treatment gap for people who use drugs, I interviewed Dr. Tony Urbina, an infectious disease physician and Professor of Medicine at the Icahn School of Medicine. Dr. Urbina is also the Medical Director of the New York State Clinical Education Initiative HIV Primary Care and Prevention Center of Excellence.