When Isaac Newton looked back over his amazing career as a scientist, he said that he just felt like a boy playing on the sea-shore, finding pebbles and shells, when a whole ocean lay before him. Every scientist is very willing to recognise that there is still a lot to be discovered in science. The same is true of Darwin. The big thing he knew very little about was actually very, very tiny—it’s the living cell. And the big question we are going to address in this program is: “How did life begin?”